Do you have a problem that nobody can solve?

Have you been going around in circles with your physical or mental health, constantly hitting walls with doctors, therapists, and coaches? Are you frustrated with the results you have been getting, knowing deep inside that “there must be a better way” or that a key exists to unlocking your full potential? If so, then consider a personal consultation with Transcend Genomics founder and Chief Scientist, John Ledford Gregory.

John Ledford GregoryWith over 20 years of exhaustive research, experimentation, and clinical experience, John has helped hundreds of individuals around the world not only resolve complex, long-standing health issues but also achieve the greatest physical and mental performance of their lives. Using his deep knowledge of molecular biology, biochemistry, genetics, transcriptomics, and functional medicine, John has created the most advanced, cutting-edge process for genetics-based root-cause analysis using a revolutionary, patent-pending pathway-modeling methodology called BiopathFxTM.

With the help of this proprietary methodology, your past medical history, symptoms, and lifestyle are viewed in a fresh, new light that eliminates going down “blind alleys” or guessing about symptoms from lab tests alone, as most modern practitioners do. By honing in on the vulnerable areas in your health, including those that may not yet be symptomatic — actionable, individualized plans for body and mind optimization may be created with astounding accuracy.

Read more about client experiences on the testimonials page.

Areas of Expertise

Aging and Longevity

Gene-Targeted Therapies, Libido Restoration, Cellular Senescence Inhibition, Growth Hormone Optimization, DNA Repair, Telomerase Reactivation, Oxidative Stress Reduction, Sustainable Cancer Prevention, Peptide-Based Therapies

Weight Management

Strategies for Fat Loss / Muscle Gain, Metabolic Rate Calibration, Tailored Diet and Exercise Plans, Hunger Control

Mental Health

Anxiety, Depression, Anhedonia, Bipolar Disorder, PTSD, Depersonalization / Derealization, Psychosis, Schizophrenia, OCD, Narcissistic Personality Disorder, Amnesia, Sensation Seeking

Immunological Disorders and Infections

Autism, Chronic Fatigue, CIRS, High Histamine / MCAD, Lyme, Parasites / Gram-Negative Bacteria, Chronic Viral Infections (e.g. Herpes Simplex, Epstein-Barr, Varicella, Cytomegalovirus), Immunodeficiency

Autoimmune Diseases

Lupus, Psoriasis, Vitiligo, Addison’s, Thyroiditis, Sjogren’s Syndrome, Ulcerative Colitis, Rheumatoid Arthritis, Fibromyalgia, Myasthenia Gravis, Demyelinating Polyneuropathy, Multiple Sclerosis, Meniere’s, Behcet’s


Opioids / Pain Killers, Alcohol, Nicotine, Benzodiazapines, Cocaine, Amphetamines / Methamphetamine, Barbituates, Heroin, Methodone / Buprenorphine, Ketamine

Endocrine Function

HPAT-Axis (hypothalamus-pituitary-adrenals-thyroid), Insulin Resistance, Diabetes Type I/II, Pineal Health, Hypoglycemia, Parathyroid, PCOS

Brain and Cognitive Disorders

Post-Concussion / TBI Rehabilitation, Learning Disabilities, ADD / ADHD, Alzheimer’s, Parkinson’s, Dementia, Brain Fog / Mental Confusion, Migraines

Cardiovascular Health

Hypo / Hypertension, Coagulation Disorders, Arrhythmia / Palpitations, Stroke Prevention / Recovery, Cholesterol Optimization

GI Disorders

Dysbiosis, Food Intolerances / Allergies, Crohn’s, IBS / IBD, SIBO, GERD, Endotoxemia, Celiac, Candida

Sleep Issues / Circadian Rhythm

Chronic Insomnia, Early Waking, Absence of Dreams, Sleep Apnea, Nightmare Control, Sleep Environment Optimization, Non-REM / REM Balance

Detoxification / Environmental Sensitivities

Heavy Metal Toxicity, Multiple Chemical Sensitivity (MCS), Electromagnetic Hypersensitivity Syndrome (EHS), Comprehensive Environmental Assessment, Phase I / II Detox Pathway Optimization

Mitochondrial Health

Disorders of Beta-Oxidation, Complex I-V MtDNA Assessment, Suboptimal Thermogenesis, Free Radical Damage, Deficits in ATP Production


Suboptimal Cholesterol / Pregnenolone Metabolism, Testosterone / Estrogen Deficiencies, Estrogen Dominance, Cancer Mitigation through Metabolite Control, Leptin / Adiponectin Balance


Enhanced Motor Skills and Sports Performance, Speed Reading, Accelerated Information Processing, Advanced Problem Resolution, Enhanced Creativity / Idea Generation, Development of Higher Artistic Capability, Brain Re-Modeling with Advanced Meditation and Neurofeedback, Strengthening of Memory (Working, Short, and Long-Term)

What makes our program different?

By working with John Ledford Gregory, you will have on your side a world-class researcher, scientist, and mentor capable of guiding you through every step on your journey to optimal wellness. Each client’s case is treated with utmost care, attention, and consideration to ensure no rock has been left unturned. Regardless of the challenges you face or personal goals you have set for yourself, John will work with you, one-on-one, to understand your circumstance and particular needs at the deepest level possible.

Numerous benefits include:

• No limitations set on care strategies by medical boards or insurance companies. Because John is not a medical doctor but a scientist and researcher, a much wider array of potential options will be offered to you

• Time spent on client consultations each week is tightly controlled so as to continually include comprehensive research. You can rest assured that the information you receive is cutting edge and up to date on all the latest trends.

• A formal medical diagnosis is not required to engage in the program. Regardless of your medical history, we can find a starting point that best suits you and your current needs. No matter your budget, we can formulate a plan that will be affordable, actionable, and results-oriented.

• You are treated as a peer and a friend rather than a patient. Each client in the  Transcend Genomics program is considered to be part of a larger family, and everyone receives the same level of attention, respect, and dedication.

Whether you are struggling with a chronic illness or looking to accomplish a physically or mentally challenging goal, consulting with John Ledford Gregory will give you all the necessary keys to unlock your highest physical and mental performance and beyond. At every step of the process, you will be provided with detailed explanations, instructions, and expert guidance that will leverage knowledge about your DNA and medical history to help you achieve all of your goals with zero confusion.

DNA services we work with

There are multiple ways to engage in this program. Given that the most effective results are seen when integrating your personal DNA data, it is recommended that you first sequence your DNA prior to scheduling a consultation. Here is a sampling of the  services we analyze data for:

If you have DNA data from another company, don’t worry – we can accommodate you, as long as it is in one of the standard formats (e.g. VCF, EMBL, BAM).

NOTE: We no longer accept data files from Dante Labs, given the consistently high level of inaccuracy we have seen in their datasets in combination with a completely absent customer service presence. If you have Dante Labs data, please consider using one of the options above instead.

Don’t have DNA Data?

Our process is unique and results are highly enriched with DNA data. Nonetheless, we understand that some individuals may either have reservations about sequencing their DNA or have not yet had an opportunity to do so. In such cases, you can still be accepted into the program, but analysis will require a more substantial medical history with supporting labs. At this time, consultations cannot be offered to individuals with nothing more than a list of symptoms unless they consent to additional testing, as there is no scientifically valid way to correlate symptoms to strategies or therapeutic options in any meaningful way.

In order to participate in the program without DNA data, you must choose either the Monthly Subscription or Hourly Consulting option. Below you will find a list of all available options for working with our program.

Consulting Options

Are you looking to go deeper?